Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SS18L1 |
| Gene Name: | SS18L1 |
| Protein Full Name: | Calcium-responsive transactivator |
| Alias: | CREST; KIAA0693; S18L1; SS18-like 1; Synovial sarcoma translocation gene on chromosome 18-like 1; SYT 1 |
| Mass (Da): | 42990 |
| Number AA: | 396 |
| UniProt ID: | O75177 |
| Locus ID: | 26039 |
| COSMIC ID: | SS18L1 |
| Gene location on chromosome: | 20q13.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20238 |
| Percent of cancer specimens with mutations: | 0.01 |
| Deregulated in translocations: | SSX1 |
| Normal role description: | In response to calcium it is involved in trancscriptional activator that interacts with CREBBP. In cancer, altered transcription due to translocation induces dysregulation and results in synovial sarcoma. |