Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | LRP5 |
| Gene Name: | LRP5 |
| Protein Full Name: | Low-density lipoprotein receptor-related protein 5 |
| Alias: | BMND1; EVR1; HBM; low density lipoprotein receptor-related pr; low density lipoprotein receptor-related protein 5; low-density lipoprotein receptor-related 5; LR3; LRP7; OPPG; OPS; VBCH2 |
| Mass (Da): | 179145 |
| Number AA: | 1615 |
| UniProt ID: | O75197 |
| Locus ID: | 4041 |
| COSMIC ID: | LRP5 |
| Gene location on chromosome: | 11q13.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20198 |
| Percent of cancer specimens with mutations: | 1.31 |
| Normal role description: | Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signalling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signalling, which plays a pivotal role in bone formation. Mutations have been implicated in many metabolic and bone-related abnormalities but also described for breast and parathyroid cancer. This is likely on the basis of disregulation of the Wnt signalling pathway. |