Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PDCD6 |
| Gene Name: | PDCD6 |
| Protein Full Name: | Programmed cell death protein 6 |
| Alias: | Apoptosis-linked gene 2 protein |
| Mass (Da): | 21850 |
| Number AA: | 191 |
| UniProt ID: | O75340 |
| Locus ID: | 10016 |
| COSMIC ID: | PDCD6 |
| Gene location on chromosome: | 5p15.33 |
| Cancer protein type: | OP/TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 19782 |
| Percent of cancer specimens with mutations: | 0.14 |
| Normal role description: | PDCD6 is a calcium binding protein which contains five EF-hand domains. PDCD6 is a factor which may mediated calcium signalled cell death but as not found to be an essential factor for apoptosis. PDCD6 has been found to interact with several targets involved in intracellular trafficking including Sec31a and TSG101. A correlation with PDCD6 expression and cancer development is ambiguous. In ocular melanomas PDCD6 expression is downregulated while in lung cancer PDCD6 is upregualted. PDCD6 may have mixed functions in regards to cancer. |