Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | FLNB |
| Gene Name: | FLNB |
| Protein Full Name: | Filamin B |
| Alias: | ABP-278; ABP-278;Filamin 3; ABP-280 homolog; Actin-binding-like protein; Beta-filamin; Filamin 3; Filamin homolog 1; Filamin-B; Thyroid autoantigen; Truncated actin-binding protein |
| Mass (Da): | 281616 |
| Number AA: | 2633 |
| UniProt ID: | O75369 |
| Locus ID: | 2317 |
| COSMIC ID: | FLNB |
| Gene location on chromosome: | 3p14.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20123 |
| Percent of cancer specimens with mutations: | 2.01 |
| Normal role description: | FLNB is involved in binding actin cytoskeleton and connecting cell membrane constituents such as transmembrane proteins and glycoproteins to actin cytoskeleton. It also has roles in binding glycoprotein Ib alpha in vasuclar injury repair, interacting with FLNA for neuroblast migration, myotube morphology and morphogenesis and muscle differentiation. |