Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TACC1 |
| Gene Name: | TACC1 |
| Protein Full Name: | Transforming acidic coiled-coil-containing protein |
| Alias: | Gastric cancer antigen Ga55; KIAA1103; Taxin 1; Transforming, acidic coiled-coil containing protein 1 |
| Mass (Da): | 87794 |
| Number AA: | 805 |
| UniProt ID: | O75410 |
| Locus ID: | 6867 |
| COSMIC ID: | TACC1 |
| Gene location on chromosome: | 8p11.22 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.53 |
| Normal role description: | The role of TACC1 is unclear. However, it has been proposed to function in microtubule dynamics in interphase, mitosis, and cytokinesis. Deregulation of this gene is assocaited with several neoplams, including: breast, ovarian, gastric, kidney, and prostate cancer. |