Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MAF |
| Gene Name: | MAF |
| Protein Full Name: | Transcription factor Maf |
| Alias: | Proto-oncogene c-maf; Transcription factor Maf; V-maf musculoaponeurotic fibrosarcoma oncogene; V-maf musculoaponeurotic fibrosarcoma oncogene homologue |
| Mass (Da): | 41961 |
| Number AA: | 373 |
| UniProt ID: | O75444; Q71A33 |
| Locus ID: | 4094 |
| COSMIC ID: | MAF |
| Gene location on chromosome: | 16q23.1 |
| Cancer protein type: | OP/TSP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 20484 |
| Percent of cancer specimens with mutations: | 0.27 |
| Deregulated in translocations: | t(14;16)(q32;q23): no fusion protein, overexpression of MAF |
| Transduced into viral genome: | AS42 sarcoma virus - Chicken |
| Normal role description: | MAF is a b-ZIP transcription factor of the AP-1 super-family, that forms homo- and heterodimers nand plays a critical role in lens development by regulating the expression of crystallins. Increases expression of IL4 in Th2 cells and the susceptibility of T cells to apoptosis by interacting with MYB and decreasing BCL2 expression. Involved in initial chondrocyte terminal differentiation. Overexpression found in multiple myeloma, due to a translocation, and in angioimmunoblastic T cell lymphoma. Suggested to be an oncogene. However tumour suppressor activity has been observed in different tissues. |