Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | E2F6 |
| Gene Name: | E2F6 |
| Protein Full Name: | Transcription factor E2F6 |
| Alias: | E2F transcription factor 6; E2F transcription factor 6, isoform 1; E2F-6 |
| Mass (Da): | 31825 |
| Number AA: | 281 |
| UniProt ID: | O75461 |
| Locus ID: | 1876 |
| COSMIC ID: | E2F6 |
| Gene location on chromosome: | 2p25.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19905 |
| Percent of cancer specimens with mutations: | 0.21 |
| Normal role description: | E2F6 heterodimerizes with DP family members and creates a sequence-specific transcriptional repressor. Overexpression of the gene can delay the exit of cells from S-phase, and E2F6 may thus in cell-cycle control. |