Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SUPT3H |
| Gene Name: | SUPT3H |
| Protein Full Name: | Transcription initiation protein SPT3 homolog |
| Alias: | SPT3; SPT3L; SPT3-like protein; Suppressor of Ty 3; SUPT3; Transcription initiation protein SPT3 |
| Mass (Da): | 35793 |
| Number AA: | 399 |
| UniProt ID: | O7548 |
| Locus ID: | 8464 |
| COSMIC ID: | SUPT3H |
| Gene location on chromosome: | 6p21.1-p21.3 |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.33 |
| Commentary on involvement of protein in cancer: | Component of the PCAF complex, at least composed of TADA2L/ADA2, SUPT3H, TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP. Associates with TAFII31 and GCN5L2. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, GCN5L2/GCN5, TAF10 and TRRAP. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. The STAGA core complex is associated with a subcomplex required for histone deubiquitinylation composed of ATXN7L3, ENY2 and USP22. |