Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CYP7B1 |
| Gene Name: | CYP7B1 |
| Protein Full Name: | 25-hydroxycholesterol 7-alpha-hydroxylase |
| Alias: | Cytochrome P450 7B1 |
| Mass (Da): | 58256 |
| Number AA: | 506 |
| UniProt ID: | O75881 |
| Locus ID: | 9420 |
| COSMIC ID: | CYP7B1 |
| Gene location on chromosome: | 8q21.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19626 |
| Percent of cancer specimens with mutations: | 0.84 |
| Normal role description: | CYB7B1 is a steroid hydroxylase that catalyzes the first step of cholesterol catabolic pathway of extrahepatic tissues. Involved in the metabolism of neurosteroids, sex hormones and oxysterols. Reactions catalyzed by CYB7B1 may eliminate the steroids from the cell. High expression levels were associated with prostatic neoplasia and adenocarcinoma. |