Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PIAS2 |
| Gene Name: | PIAS2 |
| Protein Full Name: | E3 SUMO-protein ligase PIAS2 |
| Alias: | Protein inhibitor of activated STAT2 |
| Mass (Da): | 68240 |
| Number AA: | 621 |
| UniProt ID: | O75928 |
| Locus ID: | 9063 |
| COSMIC ID: | PIAS2 |
| Gene location on chromosome: | 18q21.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20238 |
| Percent of cancer specimens with mutations: | 0.42 |
| Normal role description: | PIAS2 is a protein inhibitor that functions as an E3-type small ubiquitin-like modifier (SUMO) ligase; as a SUMO-tethering factor; and as a transcriptional co-regulator in various cellular pathways such as the STAT-, p53-, and steroid hormone pathways, most frequently leading to silencing of gene expression, although it can also lead to transactivation depending on the isoform of PIAS2 and the pathway involved. |
| Commentary on involvement of protein in cancer: | 1 pharyngeal- & 1/186 breast cancer samples were also mutated |