Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SNCG |
| Gene Name: | SNCG |
| Protein Full Name: | Gamma-synuclein |
| Alias: | BCSG1; Breast cancer-specific gene 1 protein; Persyn; PRSN; Sensory neuron synuclein; SR; Synoretin; Synuclein, gamma; Synuclein, gamma (breast cancer-specific protein 1); SYUG |
| Mass (Da): | 13331 |
| Number AA: | 127 |
| UniProt ID: | O76070 |
| Locus ID: | 6623 |
| COSMIC ID: | SNCG |
| Gene location on chromosome: | 10q23.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.1 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | SNCG plays a role in neurofilament network integrity and modulates axonal architecture during development, and may partake in keratin maintenance in skin. It promotes the degradation of neurofilament-H by calcium-dependent proteases. It can also take part in signalling and activate the MAPK/ELK-1 pathway. Mutations and overexpression have been associated with breast tumour development and metastasis. |