Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CIAO1 |
| Gene Name: | CIAO1 |
| Protein Full Name: | Probable cytosolic iron-sulfur protein assembly pr |
| Alias: | WD repeat-containing protein 39 |
| Mass (Da): | 37822 |
| Number AA: | 339 |
| UniProt ID: | O76071 |
| Locus ID: | 9391 |
| COSMIC ID: | CIAO1 |
| Gene location on chromosome: | 2q11.2 |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.19 |
| Commentary on involvement of protein in cancer: | Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. |