Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | WISP2 |
| Gene Name: | WISP2 |
| Protein Full Name: | WNT1-inducible-signaling pathway protein 2 |
| Alias: | CCN family member 5;Connective tissue growth factor-like protein;Connective tissue growth factor-related protein 58 |
| Mass (Da): | 26825 |
| Number AA: | 250 |
| UniProt ID: | O76076 |
| Locus ID: | 8839 |
| COSMIC ID: | WISP2 |
| Gene location on chromosome: | 20q12-13 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19536 |
| Percent of cancer specimens with mutations: | 0.27 |
| Found in amplified chromosomal regions in human cancers: | in breast tumours |
| Normal role description: | Secreted regulatory protein. May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production. Expression reduced in colon tumours, whereas other WISP family members are overexpressed. |