Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RECQL5 |
| Gene Name: | RECQL5 |
| Protein Full Name: | ATP-dependent DNA helicase Q5 |
| Alias: | FLJ90603; RecQ 5; RecQ protein 5; RecQ protein-like 5; RECQ5 |
| Mass (Da): | 108858 |
| Number AA: | 991 |
| UniProt ID: | O9476 |
| Locus ID: | 9400 |
| COSMIC ID: | RECQL5 |
| Gene location on chromosome: | 17q25.2-25.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20115 |
| Percent of cancer specimens with mutations: | 0.69 |
| Normal role description: | Based on sequence similarity to RecQ helicases, RECQL5 is thought to be a DNA helicase that plays an important role in genome stability. RECQL5 seems to prevent inappropriate homologous recombination via RAD51 presynaptic filament disruption. Few mutation of this gene have been found in tumors. |