Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RHOBTB1 |
| Gene Name: | RHOBTB1 |
| Protein Full Name: | Rho-related BTB domain-containing protein 1 |
| Alias: | KIAA0740; RHBT1 |
| Mass (Da): | 79417 |
| Number AA: | 696 |
| UniProt ID: | O94844 |
| Locus ID: | 9886 |
| COSMIC ID: | RHOBTB1 |
| Gene location on chromosome: | 10q21.2 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.65 |
| Normal role description: | RHOBTB1 is involved in signal transduction, regulation of actin filament system, and expression of CXCL14 in keratinocytes. Its expression is often reduced or lost in head and neck cancers resulting in loss of regulation resulting in cell migration and angiogenesis. |