Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SORBS2 |
| Gene Name: | SORBS2 |
| Protein Full Name: | Sorbin and SH3 domain-containing protein 2 |
| Alias: | Arg/Abl-interacting protein 2 |
| Mass (Da): | 71899 |
| Number AA: | 1100 |
| UniProt ID: | O94875 |
| Locus ID: | 8470 |
| COSMIC ID: | SORBS2 |
| Gene location on chromosome: | 4q35.1 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBIT |
| Number of cancer specimens: | 19673 |
| Percent of cancer specimens with mutations: | 1.05 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | t(4;11)(q35;q23) with MLL in acute myeloid leukemia |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | SORBS2 is an adaptor protein that links ABL kinases and cytoskeletal actin. It promotes the degradation of ABL1 via CBL-mediated ubiquination and subsequent proteolysis by the proteasome. SORBS2 exhibits anti-apoptosis activity via activation of PAK1. However, it can also bind vinculin and inhibit cell migration. Expression of SORBS2 is repressed in pancreatic cancer. A t(4;11)(q35;q23) translocation with MLL has been associated with acute myeloid leukemia. |