Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | DKK1 |
| Gene Name: | DKK1 |
| Protein Full Name: | Dickkopf-related protein 1 |
| Alias: | SK |
| Mass (Da): | 28672 |
| Number AA: | 266 |
| UniProt ID: | O94907 |
| Locus ID: | 22943 |
| COSMIC ID: | DKK1 |
| Gene location on chromosome: | 10q11.2 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20237 |
| Percent of cancer specimens with mutations: | 0.34 |
| Gene undergoes hypermethylation: | DKK-1 is silenced in colon cancer by DNA hypermethylation and this correlates with advanced Dukes' stages of colorectal tumorigenesis |
| Normal role description: | DKK1 is a secreted protein with two cys-rich regions that functions to inhibit Wnt signalling. It is involved in embryonic development and in vertebrate development, through local inhibition of Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. It is downregulated (by hypermethylation) in colon cancer. |