Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | FRYL |
| Gene Name: | FRYL |
| Protein Full Name: | Protein furry homolog-like |
| Alias: | ALL1-fused gene from chromosome 4p12; DKFZp686E205; FRY-like; Furry-like; KIAA0826 |
| Mass (Da): | 339598 |
| Number AA: | 3013 |
| UniProt ID: | O94915 |
| Locus ID: | 285527 |
| COSMIC ID: | FRYL |
| Gene location on chromosome: | 4p12; 4p11 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19606 |
| Percent of cancer specimens with mutations: | 1.77 |
| Deregulated in translocations: | Acute Lymphoblastic Leukaemia. Fusion partner MLL. |
| Normal role description: | FRYL is a widely expressed protein which may function as a transcriptional activator. In the cell FRYL appears to function in regulating actin skeleton and maintaining the polarity of cells during morphogenesis. FRYL is implicated in the development of acute lymphoblastic leukemia as a fusion partner with mixed lineage leukemia (MLL) protein. |