Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NKX2-2 |
| Gene Name: | NKX2-2 |
| Protein Full Name: | Homeobox protein Nkx-2.2 |
| Alias: | Homeobox protein NK-2 homolog B |
| Mass (Da): | 30133 |
| Number AA: | 273 |
| UniProt ID: | O95096 |
| Locus ID: | 4821 |
| COSMIC ID: | NKX2-2 |
| Gene location on chromosome: | 20p11.22 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.54 |
| Deregulated in translocations: | Ewing's Sarcoma, fusion partner is FLI-1. |
| Normal role description: | NKX2-2 is a nuclear localized transcription factor that may be involved in early cellular development of pancreatic beta cells and neurons of the central nervous system. The NKX2-2 gene locus can participate in a translocation event leading to a fusion protein implicated in Ewing's sarcoma. |