Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TNFSF15 |
| Gene Name: | TNFSF15 |
| Protein Full Name: | Tumor necrosis factor ligand superfamily member 15 |
| Alias: | TNF ligand-related molecule 1;Vascular endothelial cell growth inhibitor |
| Mass (Da): | 28087 |
| Number AA: | 251 |
| UniProt ID: | O95150 |
| Locus ID: | 9966 |
| COSMIC ID: | TNFSF15 |
| Gene location on chromosome: | 9q32 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19719 |
| Percent of cancer specimens with mutations: | 0.26 |
| Normal role description: | TNFSF15 is a cytokine secreted by endothelial cells. TNFSF15 will activated a receptor TNFRSF25 to activate MAPK p38 and JNK signalling pathways. TNFSF15 was found to induce apoptosis in proliferating endothelial cells and inhibit angiogenesis. TNFSF15 is also found to mediate immune responses through T-cell activation. TNFSF15 has been suggested to act as a tumour suppressor protein due to its proapoptotic and antiproliferative effects on endothelial cell growth. Injection of TNFSF15 in colon cancer and breast cancer models was shown to suppress tumour growth thus support a tumour suppressor role for TNFSF15. |