Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | UBE4B |
| Gene Name: | UBE4B |
| Protein Full Name: | Ubiquitin conjugation factor E4 B |
| Alias: | HDNB1; Homozygously deleted in neuroblastoma-1; KIAA0684; UB4B; Ubiquitin fusion degradation protein 2; Ubiquitin-fusion degradation protein 2; UFD2 |
| Mass (Da): | 146185 |
| Number AA: | 1302 |
| UniProt ID: | O95155 |
| Locus ID: | 10277 |
| COSMIC ID: | UBE4B |
| Gene location on chromosome: | 1p36.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19805 |
| Percent of cancer specimens with mutations: | 0.99 |
| Normal role description: | UBE4B plays a central role in the ubiquitination of proteins. In this capacity, UBE4B (E4) binds to the ubiquitin moieties and catalyzes ubiquitin chain assembly; it does this in conjunction with E1, E2, and E3 enzymes. Mutations in this gene have been observed in ovarian, skin, and laryngeal tumors. |