Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ZWINT |
| Gene Name: | ZWINT |
| Protein Full Name: | ZW10 interactor |
| Alias: | Kntc2ap; ZW10-interacting protein 1; ZWINT1; ZWINT-1 |
| Mass (Da): | 31275 |
| Number AA: | 277 |
| UniProt ID: | O95229 |
| Locus ID: | 11130 |
| COSMIC ID: | ZWINT |
| Gene location on chromosome: | 10q21.1 |
| Cancer protein type: | TSP? |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19719 |
| Percent of cancer specimens with mutations: | 0.33 |
| Normal role description: | ZWINT is a component in the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. It is required to target ZW10 to the kinetochore at prometaphase and is present in kinetechores from late prophase to anaphase. It might be a mitotic checkpoint protein. |
| Commentary on involvement of protein in cancer: | No transforming mutations were identified in the Atlas of Gene Oncology, the Sanger COSMIC database, or Uniprot for this gene. |