Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TACC2 |
| Gene Name: | TACC2 |
| Protein Full Name: | Transforming acidic coiled-coil-containing protein |
| Alias: | Anti zuai-1; Anti Zuai-1; AZU-1; ECTACC; Transforming acidic coiled-coil-containing protein 2; Transforming, acidic coiled-coil containing protein 2 |
| Mass (Da): | 309427 |
| Number AA: | 2948 |
| UniProt ID: | O95359 |
| Locus ID: | 10579 |
| COSMIC ID: | TACC2 |
| Gene location on chromosome: | 10q26.13 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19782 |
| Percent of cancer specimens with mutations: | 2.04 |
| Normal role description: | TACC2 is a protein that interacts with centrosomes and microtubules during cell cycle progression. TACC2 protein expression has been correlated with breast cancer development, however the specific function within the cancer system is not clear. |