Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ZBTB7A |
| Gene Name: | ZBTB7A |
| Protein Full Name: | Zinc finger and BTB domain-containing protein 7A |
| Alias: | FBI1; Leukemia/lymphoma-related factor; TIP21 |
| Mass (Da): | 61439 |
| Number AA: | 584 |
| UniProt ID: | O95365 |
| Locus ID: | 51341 |
| COSMIC ID: | ZBTB7A |
| Gene location on chromosome: | 19p13.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.41 |
| Normal role description: | ZBTB7A is a transcription factor responsible for regulating the expression of various proteins, such as extracellular matrix collagen types I, II, IX, X and XI, fibronectin, elastin, human cartilage oligomeric matrix protein, p19ARF, and the c-fos and c-myc oncoproteins, by binding to consensus sequence within their promoters. It plays a role in cell growth, proliferation, and differentiation. It partially colocalizes with Tat, a viral transactivator protein, responsible for the synthesis of HIV-1 full-length transcripts, and enhances its activity in a dose dependent manner, thereby modulating Tat-activated HIV-1 transcription. ZBTB7A is over-expressed in many cancers, and has been found to repress the transcription of the tumour suppressors p14ARF and Rb, and is hence considered to be a proto-oncogene. |