Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TNFAIP8 |
| Gene Name: | TNFAIP8 |
| Protein Full Name: | Tumor necrosis factor alpha-induced protein 8 |
| Alias: | Head and neck tumor and metastasis-related protein |
| Mass (Da): | 21877 |
| Number AA: | 198 |
| UniProt ID: | O95379 |
| Locus ID: | 25816 |
| COSMIC ID: | TNFAIP8 |
| Gene location on chromosome: | 5q23. |
| Number of cancer specimens: | 19557 |
| Percent of cancer specimens with mutations: | 0.01 |
| Commentary on involvement of protein in cancer: | Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation. |