Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MAP3K6 |
| Gene Name: | MAP3K6 |
| Protein Full Name: | Mitogen-activated protein kinase kinase kinase 6 |
| Alias: | Apoptosis signal regulating kinase 2; ASK2; EC 2.7.11.25; Kinase MAP3K6; M3K6; MAP3K6; MAPKKK6; MEK kinase 6 |
| Mass (Da): | 142596 |
| Number AA: | 1288 |
| UniProt ID: | O95382 |
| Locus ID: | 9064 |
| COSMIC ID: | MAP3K6 |
| Gene location on chromosome: | 1p36.11 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19535 |
| Percent of cancer specimens with mutations: | 0.03 |
| Normal role description: | MAP3K6 is a protein-serine/threonine kinase. It is involved in signal transduction and activtion of c-JUN kinase and p38. Dysregulated signalling can lead to oncogenesis. |