Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | WISP3 |
| Gene Name: | WISP3 |
| Protein Full Name: | WNT1-inducible-signaling pathway protein 3 |
| Alias: | CCN family member 6 |
| Mass (Da): | 39293 |
| Number AA: | 354 |
| UniProt ID: | O95389 |
| Locus ID: | 8838 |
| COSMIC ID: | WISP3 |
| Gene location on chromosome: | 6q22-q23 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19626 |
| Percent of cancer specimens with mutations: | 0.29 |
| Normal role description: | The function of WISP3 is unclear, though it being a member of the WNT1 signallin pathway (WISP) protiens may indicated a role in the WNT pathway -- a pro-growth pathway. Mutations in this gene have been observed in breast and colon cancer. Loss of this gene is a key component in inflammatory breast cancer oncogenesis. |