Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TNFRSF6B |
| Gene Name: | TNFRSF6B |
| Protein Full Name: | Tumor necrosis factor receptor superfamily member |
| Alias: | Decoy receptor 3;Decoy receptor for Fas ligand;M68 |
| Mass (Da): | 32680 |
| Number AA: | 300 |
| UniProt ID: | O95407 |
| Locus ID: | 8771 |
| COSMIC ID: | TNFRSF6B |
| Gene location on chromosome: | 20q13.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.15 |
| Normal role description: | As a competitive inhibitor for TNF-related receptors, TNFRSF6B blocks TNF signalling in the extrinsic apoptosis pathway. It is believed that many types of malignant tumors gain survival advantage by secreting TNFRSF6B which blocks tumour cell apoptosis. TNFRSF6B is overexpressed in about 60% of various malignant tumors. |