Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
Protein Name: | STAMBP |
Gene Name: | STAMBP |
Protein Full Name: | STAM-binding protein |
Alias: | 5330424L14Rik protein; 5730422L11Rik protein; Associated molecule with the SH3 domain of STAM; STABP; STAM binding protein; STAMBP |
Mass (Da): | 48077 |
Number AA: | 424 |
UniProt ID: | O95630 |
Locus ID: | 10617 |
COSMIC ID: | STAMBP |
Gene location on chromosome: | 2p13.1 |
Cancer protein type: | OP |
Effect of cancer mutation on protein: | UNCLEAR |
Effect of active protein on cancer: | PROMOTES |
Number of cancer specimens: | 20057 |
Percent of cancer specimens with mutations: | 0.33 |
Normal role description: | AMSH is an adapter protein involved in cytokine/JAK/STAT signalling. AMSH is required for signal propagation that ultimately converges in MYC signalling and cell growth. AMSH is a zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains and thus prevents ubiquitin-mediated protein destruction of various targets in the JAK/STAT pathway. |