Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | DDX58 |
| Gene Name: | DDX58 |
| Protein Full Name: | Probable ATP-dependent RNA helicase DDX58 |
| Alias: | DEAD box protein 58;Retinoic acid-inducible gene 1 protein;Retinoic acid-inducible gene I protein |
| Mass (Da): | 106600 |
| Number AA: | 925 |
| UniProt ID: | O95786 |
| Locus ID: | 23586 |
| COSMIC ID: | DDX58 |
| Gene location on chromosome: | 9p12 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.7 |
| Normal role description: | DDX58 is involved in innate immune defense against viruses: upon interaction with intracellular dsRNA produced during viral replication, it triggers a transduction cascade resulting in the activation of NFκB, IRF3 and IRF7 as well as the induction of the expression of antiviral cytokines such as IFN-β. |
| Commentary on involvement of protein in cancer: | Only 2 ovarian and 1 liver sample were included in Sanger COSMIC. |