Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | AIFM1 |
| Gene Name: | AIFM1 |
| Protein Full Name: | Apoptosis-inducing factor 1, mitochondrial |
| Alias: | Aif; Apoptosis-inducing factor; Apoptosis-inducing factor, mitochondrion-associated, 1; Programmed cell death protein 8; Programmed cell death protein 8, mitochondrial |
| Mass (Da): | 66901 |
| Number AA: | 613 |
| UniProt ID: | O95831 |
| Locus ID: | 9131 |
| COSMIC ID: | AIFM1 |
| Gene location on chromosome: | Xq26.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19650 |
| Percent of cancer specimens with mutations: | 0.43 |
| Normal role description: | AIFM1 is an oxidoreductase that plays a role in cell death and cell survival. In healthy cells it is found in the mitochondrial membrane and is essential for maintaining cell integrity via its oxidoreductase activity. Induction of apoptosis triggers release of AIFM1 and translocation to the nucleus. Promotes release and/or activation of proteins involved in apoptosis, such as caspase-7 and caspase-9, and induces DNA degredation in a caspase-independent way. |