Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SNAI1 |
| Gene Name: | SNAI1 |
| Protein Full Name: | Zinc finger protein SNAI1 |
| Alias: | SLUGH2; Sna; SNAH; SNAI; Snail; Snail 1 |
| Mass (Da): | 29083 |
| Number AA: | 264 |
| UniProt ID: | O95863 |
| Locus ID: | 6615 |
| COSMIC ID: | SNAI1 |
| Gene location on chromosome: | 20q13.13 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.21 |
| Normal role description: | Trancription protein functions as an E-cadherin repressor. Increases cell motility by facilitating phenotypic change of epithelial cells to more mesenchymal appearance. SNAI1 upregulation is mediated by IL-6 and many RTKs. This phenotypic switch has been strongly correlating with increased propensity for metastasis in numerous cancer systems. |