Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | LGI1 |
| Gene Name: | LGI1 |
| Protein Full Name: | Leucine-rich glioma-inactivated protein 1 |
| Alias: | Epitempin-1 |
| Mass (Da): | 63818 |
| Number AA: | 557 |
| UniProt ID: | O95970 |
| Locus ID: | 9211 |
| COSMIC ID: | LGI1 |
| Gene location on chromosome: | 10q23.33 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19627 |
| Percent of cancer specimens with mutations: | 0.65 |
| Normal role description: | LEGI1 regulates voltage-gated potassium channel. Expression of LGI1 is negatively correlated with grade of malignancy in astrocytic gliomas. Mutations in this gene are also associated with ovarian cancer. |