Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | APC2 |
| Gene Name: | APC2 |
| Protein Full Name: | Adenomatous polyposis coli protein 2 |
| Alias: | Adenomatosis polyposis coli 2; Adenomatous polyposis coli like; Adenomatous polyposis coli protein-like; APCL |
| Mass (Da): | 243949 |
| Number AA: | 2303 |
| UniProt ID: | O95996 |
| Locus ID: | 10297 |
| COSMIC ID: | APC2 |
| Gene location on chromosome: | 19p13.3 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19781 |
| Percent of cancer specimens with mutations: | 0.75 |
| Normal role description: | APC2 is related to APC in many aspects and has many of the same functions. A difference exists in the C-termini region of APC2 that allows for p53 binding. APC2 can bind β-catenin and regulate its phosphorylation and ubiquintination. Inactivating mutations in related APC genes leads to cancer by accumlation of β-catenin leading to activation of cellular transformation signals. |