Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PTTG1 |
| Gene Name: | PTTG1 |
| Protein Full Name: | Securin |
| Alias: | EAP1; ESP1-associated protein 1; HPTTG; Pituitary tumor-transforming 1; Pituitary tumor-transforming gene 1 protein; PTTG; Tumor-transforming protein 1; TUTR1 |
| Mass (Da): | 22024 |
| Number AA: | 202 |
| UniProt ID: | O95997 |
| Locus ID: | 9232 |
| COSMIC ID: | PTTG1 |
| Gene location on chromosome: | 5q35 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.15 |
| Normal role description: | PTTG inhibits separase proteolytic activity during the cell cycle until anaphase, when the sister chromatids are separated. PTTG gene is highly expressed in a variety of tumors and enhances proliferation. It regulates angiogenesis and invasion through increased expression and secretion of matrix metalloproteinase-2 (MMP-2). |