Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ACTL6A |
| Gene Name: | ACTL6A |
| Protein Full Name: | Actin-like protein 6A |
| Alias: | ACL6A; actin-like 6A; actin-related protein 4; ACTL6; ACTL6A; Arp4; BAF complex 53 kDa subunit; Baf53a; BRG1-associated factor; INO80 complex subunit K; INO80K; MGC5382 |
| Mass (Da): | 47461 |
| Number AA: | 429 |
| UniProt ID: | O96019 |
| Locus ID: | 86 |
| COSMIC ID: | ACTL6A |
| Gene location on chromosome: | 3q26.33 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.34 |
| Normal role description: | ACTL6A encodes actin related proteins which have many functions within the cell. One of which includes regulation of transcription via chromatin remodelling. It is required for maximal activity of BAF1 and association with BAF complex with the chromatin/matrix. Regulated genes by the formed complex ranges from oncogenes, proto-oncogenes, tumour suppresor genes, apoptosis genes and DNA repair genes. |