Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TIMP1 |
| Gene Name: | TIMP1 |
| Protein Full Name: | Metalloproteinase inhibitor 1 |
| Alias: | Erythroid-potentiating activity;Fibroblast collagenase inhibitor;Tissue inhibitor of metalloproteinases 1 |
| Mass (Da): | 23171 |
| Number AA: | 207 |
| UniProt ID: | P01033 |
| Locus ID: | 7076 |
| COSMIC ID: | TIMP1 |
| Gene location on chromosome: | 7076 |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.07 |
| Normal role description: | Protease inhibitor. Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14. |