Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CSTA |
| Gene Name: | CSTA |
| Protein Full Name: | Cystatin-A |
| Alias: | Cystatin-AS;Stefin-A |
| Mass (Da): | 11006 |
| Number AA: | 98 |
| UniProt ID: | P01040 |
| Locus ID: | 1475 |
| COSMIC ID: | CSTA |
| Gene location on chromosome: | 3q21.1 |
| Cancer protein type: | OP/TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.15 |
| Normal role description: | CSTA is a protease inhibitor and an intracellular thiol proteinase inhibitor, protecting epithelial and lymphoid tissues from cysteine protesases released by invading pathogens. It forms tight complexes with papain and with cathepsin B/H/L and is one of the precursors of the cornified cell envelope in keratinocytes. It also plays a role in development and maintenance of the epidermis and possibly also in apoptosis. |
| Commentary on involvement of protein in cancer: | CSTA appears to function as a tumour suppressor in several types of cancer, but is also upregulated in many! |