Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Myc |
| Gene Name: | MYC |
| Protein Full Name: | Myc proto-oncogene protein |
| Alias: | BHLHe39; C-Myc; C-myc; Transcription factor p64; V-myc myelocytomatosis viral oncogene; V-myc myelocytomatosis viral oncogene homolog (avian) |
| Mass (Da): | 48804 |
| Number AA: | 439 |
| UniProt ID: | B3CJ64; A0N2G3; B3CJ63; B3CJ65; B3CJ66; B3CJ69; B3CJ71; B3CJ72; B3CJ73; B3CJ74; B3CJ75; B3CJ76; B3CJ77; B3CJ78; B3CJ81; B3CJ82; B3CJ86; B3CJ87; B3CJ88; B3CJ89; B3CJ90; B3CJ91; B3CJ92; B3CJ93; B3CJ94; B3CJA1; B3CJA3; B3CJA4; B3CJA7; B3CJA8; B3CJA9; B3CJA1; |
| Locus ID: | 4609 |
| COSMIC ID: | MYC |
| Gene location on chromosome: | 8q24 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 21510 |
| Percent of cancer specimens with mutations: | 0.56 |
| Found in amplified chromosomal regions in human cancers: | Various leukemias and carcinomas (10-50%), including breast, cervical and colon cancers, as well as in squamous cell carcinomas of the head and neck, myeloma, non-Hodgkin's lymphoma, gastric adenocarcinomas and ovarian cancer. |
| Deregulated in translocations: | Burkitt's lymphoma; other B- and T-cell malignancies |
| Deregulated by viral insertion: | Avian leukosis virus - Chicken; Feline leukemia virus - Cat |
| Transduced into viral genome: | Myelocytomatosis 29 virus - Chicken |
| Normal role description: | Transcription protein that promotes cell proliferation and DNA synthesis. Mutations in this gene, particularaly amplification and transclocation events are common in numerous tumors. These neoplasms include: breast, cervical and colon cancers, as well as in squamous cell carcinomas of the head and neck, myeloma, non-Hodgkin's lymphoma, gastric adenocarcinomas and ovarian cancer. |