Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NPY |
| Gene Name: | NPY |
| Protein Full Name: | Neuropeptide Y |
| Alias: | Neuropeptide tyrosine |
| Mass (Da): | 10851 |
| Number AA: | 97 |
| UniProt ID: | P01303 |
| Locus ID: | 4852 |
| COSMIC ID: | NPY |
| Gene location on chromosome: | 7p15.1 |
| Cancer protein type: | OP/TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.23 |
| Normal role description: | Neurotransmitter. Via receptor binding involved in control of appetite, body weight homeostasis, the modulation of reproductive processes, circadian rhythm, the regulation of growth hormone secretion. Also implicated in the control of vasoconstriction and regulation of cardiovascular function. NPY functions through G protein-coupled receptors and inhibits adenylyl cyclase, activates mitogen-activated protein kinase (MAPK), regulates intracellular calcium levels, and activates potassium channels. |