Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | LTA |
| Gene Name: | LTA |
| Protein Full Name: | Lymphotoxin-alpha |
| Alias: | TNF-beta;Tumor necrosis factor ligand superfamily member 1 |
| Mass (Da): | 22297 |
| Number AA: | 205 |
| UniProt ID: | P01374 |
| Locus ID: | 4049 |
| COSMIC ID: | LTA |
| Gene location on chromosome: | 6p21.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20057 |
| Percent of cancer specimens with mutations: | 0.21 |
| Normal role description: | Cytokine involved in TNF signalling. Part of the inflammatory response of lymphocytes. Although TNF signalling is upregulated in cancer tumors as part of the immune response to tumors, LTA has not been shown to specifically inhibit or promote cancer. |