Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TNF |
| Gene Name: | TNF |
| Protein Full Name: | Tumor necrosis factor |
| Alias: | Cachectin;TNF-alpha;Tumor necrosis factor ligand superfamily member 2 |
| Mass (Da): | 25644 |
| Number AA: | 233 |
| UniProt ID: | P01375 |
| Locus ID: | 7124 |
| COSMIC ID: | TNF |
| Gene location on chromosome: | 6p21.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 20151 |
| Percent of cancer specimens with mutations: | 0.16 |
| Normal role description: | TNF is a proinflammatory cytokine which can be secreted or found membrane bound. TNF will mediate its actions through binding of TNF receptors (TNFR1 and TNF2). TNF receptor activation will activate NF-kB and MAPK signalling pathways which can cause cell proliferation or apoptosis depending on the cell type being stimulated. Initial studies of TNF found it to be cyototoxic/cyotostatic to transformed cell lines and thus may have a role in regulating cancer progression. However, TNF has also been found to promote invasion and metastasis of cancer tumours. Thus the role of TNF in cancer development is still ambiguous. |