Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CRYAA |
| Gene Name: | CRYAA |
| Protein Full Name: | Alpha-crystallin A chain |
| Alias: | Alpha crystallin A chain; Crystallin, alpha A; Crystallin, alphaA; Heat shock protein beta-4; Heat-shock protein beta-4; HspB4 |
| Mass (Da): | 19909 |
| Number AA: | 173 |
| UniProt ID: | P02489 |
| Locus ID: | 1409 |
| COSMIC ID: | CRYAA |
| Gene location on chromosome: | 21q22.3 |
| Number of cancer specimens: | 19780 |
| Percent of cancer specimens with mutations: | 0.21 |
| Commentary on involvement of protein in cancer: | Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. |