Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CRYAB |
| Gene Name: | CRYAB |
| Protein Full Name: | Alpha-crystallin B chain |
| Alias: | Alpha crystallin B chain; Alpha(B)-crystallin; CRYA2; Crystallin, alpha B; Crystallin, alphaB; Heat shock protein beta-5; HSPB5; P23; Renal carcinoma antigen NY-REN-27; Rosenthal fiber component |
| Mass (Da): | 20159 |
| Number AA: | 175 |
| UniProt ID: | P02511 |
| Locus ID: | 1410 |
| COSMIC ID: | CRYAB |
| Gene location on chromosome: | 11q23.1 |
| Cancer protein type: | OP/TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.12 |
| Normal role description: | Although first described in the eye, expression in a variety of tissues and protein homology imply potential role as heat-shock protein. CRYAB has been demonstrated to activate the MEK/ERK pathway in immortalized breat epithelial cells. Expression levels have varied in human cancers with both upregulation and downregulation correlating with oncogenesis |