Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MMP1 |
| Gene Name: | MMP1 |
| Protein Full Name: | Interstitial collagenase |
| Alias: | Fibroblast collagenase;Matrix metalloproteinase-1 |
| Mass (Da): | 54007 |
| Number AA: | 469 |
| UniProt ID: | P03956 |
| Locus ID: | 4312 |
| COSMIC ID: | MMP1 |
| Gene location on chromosome: | 11q22.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.55 |
| Normal role description: | MMP1 is a matrix metalloproteinase. It is secreted and activated to degrade extracellular matrix in embryonic development, reproduction, tissue remodeling and in diseases. It is involved in degradation of collagen type I, II, III, VII and X. It is highly expressed by tumors and faciliates invasion and metastasis. |