Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Raf1 |
| Gene Name: | RAF1 |
| Protein Full Name: | RAF proto-oncogene serine/threonine-protein kinase |
| Alias: | CRAF; C-RAF; C-Raf; EC 2.7.11.1; Kinase Raf1; Murine leukemia viral (V-raf-1) oncogene homologue 1; Protein kinase raf 1; Raf proto-oncogene serine/threonine-protein kinase; RAF1; RAF-1; Raf-1; Similar to murine leukemia viral (V-raf-1) oncogene homolog 1; V-raf-1 murine leukemia viral oncogene 1 |
| Mass (Da): | 73052 |
| Number AA: | 648 |
| UniProt ID: | P04049; B4E1N6; B4E1N6; Q59HC8 |
| Locus ID: | 5894 |
| COSMIC ID: | RAF1 |
| Gene location on chromosome: | 3p25 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20796 |
| Percent of cancer specimens with mutations: | 0.62 |
| Transduced into viral genome: | 3611 murine sarcoma virus - Mouse |
| Normal role description: | RAF1 is a protein-serine/threonine kinase. RAF-1 is upregulated in many cancers since Ras (an upstream activator of RAF) is mutated/upreguated in many cancers. For example, RAF-1 is over-expressed due to oncogenic ras mutations in about 35% of Non-Small Cell Lung Cancer (NSCLC). A small number of RAF mutations have been found in stomach and mouth tumors. RAF-1 gene amplification was detected in 4% of bladder cancer samples, while deletions at the RAF-1 locus were detected in 2.2% of these samples; these amplifications and deletions were correlated with tumour grade. |