Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | A1BG |
| Gene Name: | A1BG |
| Protein Full Name: | Alpha-1B-glycoprotein |
| Alias: | Alpha-1-B glycoprotein |
| Mass (Da): | 54273 |
| Number AA: | 495 |
| UniProt ID: | P04217 |
| Locus ID: | 1 |
| COSMIC ID: | A1BG |
| Gene location on chromosome: | 19q13.43 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19626 |
| Percent of cancer specimens with mutations: | 0.44 |
| Normal role description: | A1BG is a secreted glycoprotein of unknown function that interacts with CRISP3. It may protect the circulation from a potentially harmful effect of free CRISP-3. A1BG shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins. |
| Commentary on involvement of protein in cancer: | No transforming mutations were identified in the Atlas of Gene Oncology, the Sanger COSMIC database, or Uniprot for this gene. |