Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CYP1A1 |
| Gene Name: | CYP1A1 |
| Protein Full Name: | Cytochrome P450 1A1 |
| Alias: | AHH; AHRR; Aryl hydrocarbon hydroxylase; CP11; CP1A1; CYP1; CYPIA1; Cytochrome P1-450, dioxin-inducible; Cytochrome P450 1A1 variant; Cytochrome P450, family 1, subfamily A, polypeptide 1; Cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1; Flavoprotein-linked monooxygenase; Microsomal monooxygenase; P1-450; P450 form 6; P450-C; P450DX; P450-P1; Xenobiotic monooxygenase |
| Mass (Da): | 58165 |
| Number AA: | 512 |
| UniProt ID: | P04798 |
| Locus ID: | 1543 |
| COSMIC ID: | CYP1A1 |
| Gene location on chromosome: | 15q22-q24 |
| Cancer protein type: | BOTH |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 19788 |
| Percent of cancer specimens with mutations: | 0.53 |
| Normal role description: | CYP1A1 is a monooxygenase. It is involved in NADPH-dependent electron transport pathway and synthesis of cholesterol, steroids and other lipids. It is also metabolism of drugs, xenobiotics and detoxification. It is able to metabolize polycyclic aromatic hydrocarbons to carcinogenic forms. Other important roles include regulating cell physiological and growth processes. |