Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ICAM1 |
| Gene Name: | ICAM1 |
| Protein Full Name: | Intercellular adhesion molecule 1 |
| Alias: | BB2; CD54; ICA1; ICAM-1; Intercellular adhesion molecule 1; Intercellular adhesion molecule-1 precursor; Major group rhinovirus receptor; Rhinovirus receptor |
| Mass (Da): | 57825 |
| Number AA: | 532 |
| UniProt ID: | P05362 |
| Locus ID: | 3383 |
| COSMIC ID: | ICAM1 |
| Gene location on chromosome: | 19p13.2 |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.33 |
| Normal role description: | ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus. Deregulation in this gene is associated with numerous neoplasms. |