Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Lck |
| Gene Name: | LCK |
| Protein Full Name: | Tyrosine-protein kinase Lck |
| Alias: | EC 2.7.10.2; LSK; LSK-T; P56-LCK |
| Mass (Da): | 58001 |
| Number AA: | 509 |
| UniProt ID: | P06239 |
| Locus ID: | 3932 |
| COSMIC ID: | LCK |
| Gene location on chromosome: | 1p34.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20787 |
| Percent of cancer specimens with mutations: | 0.59 |
| Deregulated in translocations: | HSB2- T-cell leukemia. Fusion partners include TCRB |
| Deregulated by viral insertion: | Moloney murine leukemia virus (MoMLV) - Mouse |
| Normal role description: | LCK is a protein-tyrosine kinase involved in T-cell development and T-cell activation. |